Topoisomerase I inhibitor 17, CAS [[2413582-45-1]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-168739
Supplier Catalog Number:
HY-168739
Alternative Catalog Number:
MCE-HY-168739-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
Topoisomerase I inhibitor 17 (Compound 7h) is a Topoisomerase I (Top1) inhibitor. Topoisomerase I inhibitor 17 reduces DDX5 and reverses the locking of Top1 activity by DDX5. Topoisomerase I inhibitor 17 induces Top1-mediated DNA damage and promotes reactive oxygen species (ROS) production. Topoisomerase I inhibitor 17 induces Apoptosis (reduces antiapoptotic proteins XIAP, Bcl-2, Survivin and up-regulates pro-apoptotic proteins Bax, gammaH2AX). Topoisomerase I inhibitor 17 also blocks the progression of the G2/M checkpoint and induces cell cycle arrest. Topoisomerase I inhibitor 17 significantly inhibits colony formation and cell migration in colorectal cancer cells. Topoisomerase I inhibitor 17 effectively reduces tumors in human PDX tumor mice[1].
Molecular Weight:
516.47
CAS Number:
[2413582-45-1]
Formula:
C28H21FN2O7
Target:
Apoptosis,Bcl-2 Family,DNA/RNA Synthesis,IAP,Reactive Oxygen Species (ROS),Survivin,Topoisomerase
Application Notes:
MCE Product type: Reference compound1
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