TRAP-1 (XJZ-06-462) is a selective p53Y220C transcriptional activator. TRAP-1 can engage p53Y220C and BRD4 in a ternary complex, which potently activates mutant p53 and triggers robust p53 target gene transcription. TRAP-1 rapidly upregulates p21 and other p53 target genes in pancreatic cell lines with p53Y220C. TRAP-1 exhibits higher antiproliferative activity in BxPC-3 (p53Y220C) cells than in A549 cells (p53WT), with IC50 values of 0.531 µM and 3.94 µM, respectively. TRAP-1 can be used for the study of p53Y220C-bearing cancer.
Molekulargewicht:
1108.69
Reinheit:
99.69
Formel:
C57H66ClF3N11O3PS
Target-Kategorie:
Apoptosis,MDM-2/p53
Anwendungsbeschreibung:
Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
