TRAP-1 (XJZ-06-462) is a non-covalent regulated induced proximity targeting chimera (RIPTAC) with JQ-1 carboxylic acid (HY-78695) as its target protein ligand. TRAP-1 forms a ternary complex with p53Y220C and BRD4, potently activates p53 transcription, and inhibits the growth and proliferation of tumor cells. TRAP-1 upregulates p21 and other p53 target genes in pancreatic cell lines carrying p53Y220C, and induces cellular senescence and apoptosis. TRAP-1 can be used in cancer research involving p53Y220C-carrying tumors[1].
Molecular Weight:
1108.69
Purity:
99.69
CAS Number:
[3109600-48-5]
Formula:
C57H66ClF3N11O3PS
Target:
Apoptosis,MDM-2/p53
Application Notes:
MCE Product type: Reference compound
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