Gemcitabine triphosphate, CAS [[110988-86-8]] Preis auf Anfrage

Produktübersicht

• Artikelname: Gemcitabine triphosphate, CAS [[110988-86-8]] Preis auf Anfrage
• Artikelnummer: MCE-HY-17026A
• Hersteller Artikelnummer: HY-17026A
• Alternativnummer: MCE-HY-17026A-1UNIT
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien
• Alternative Synonym: dFdCTP

Produktbeschreibung

Gemcitabine triphosphate (dFdCTP) is the active metabolite of Gemcitabine (HY-17026). The mechanism of Gemcitabine triphosphate cell-killing is its competition with cytidine triphosphate during DNA replication, which results in the inhibition of chain elongation. Gemcitabine triphosphate shows a Ki of 11.2 µM against DNA polymerase alpha and 14.4 µM against DNA polymerase epsilon. Gemcitabine triphosphate partially inhibits dCMP deaminase and acts as a substrate for DNA synthesis to incorporate into cellular DNA and RNA. Gemcitabine triphosphate disrupts DNA and RNA synthesis, arrests cell cycle in G0/G1 and S phases, triggers apoptosis, reduces tumor cell proliferation. Gemcitabine triphosphate can be used for the research of pancreatic cancer and non-small cell lung cancer[1][2][3][4].

Produkteigenschaften

• Molekulargewicht: 503.14
• CAS Nummer: [110988-86-8]
• Formel: C9H14F2N3O13P3
• Target-Kategorie: Apoptosis,DNA/RNA Synthesis,Drug Metabolite

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound