Gemcitabine triphosphate, CAS [[110988-86-8]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-17026A
Supplier Catalog Number:
HY-17026A
Alternative Catalog Number:
MCE-HY-17026A-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
Alternative Names:
dFdCTP
Gemcitabine triphosphate (dFdCTP) is the active metabolite of Gemcitabine (HY-17026). The mechanism of Gemcitabine triphosphate cell-killing is its competition with cytidine triphosphate during DNA replication, which results in the inhibition of chain elongation. Gemcitabine triphosphate shows a Ki of 11.2 µM against DNA polymerase alpha and 14.4 µM against DNA polymerase epsilon. Gemcitabine triphosphate partially inhibits dCMP deaminase and acts as a substrate for DNA synthesis to incorporate into cellular DNA and RNA. Gemcitabine triphosphate disrupts DNA and RNA synthesis, arrests cell cycle in G0/G1 and S phases, triggers apoptosis, reduces tumor cell proliferation. Gemcitabine triphosphate can be used for the research of pancreatic cancer and non-small cell lung cancer[1][2][3][4].
Molecular Weight:
503.14
CAS Number:
[110988-86-8]
Formula:
C9H14F2N3O13P3
Target:
Apoptosis,DNA/RNA Synthesis,Drug Metabolite
Application Notes:
MCE Product type: Reference compound
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