PROTAC AR Degrader-9 (Compound c6) is a PROTAC degrader for androgen receptor, that degrades AR in human hair follicle papilla cells (HDPCs) with a DC50 of 262.38 nM. PROTAC AR Degrader-9 promotes the expressions of paracrine factors, such as TGF-beta1 and beta-catenin, exhibits hair regenerating efficacy in mouse models[1]. (Pink: ligand for target protein AR ligand-38 (HY-170450), Black: linker, Blue: ligand for E3 ligase Cereblon (HY-170449))
Molekulargewicht:
765.34
Formel:
C43H49ClN6O5
Target-Kategorie:
Androgen Receptor,PROTACs
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
