Seldegamadlin, CAS [[2713618-08-5]]

Produktübersicht

• Artikelname: Seldegamadlin, CAS [[2713618-08-5]]
• Artikelnummer: MCE-HY-170451
• Hersteller Artikelnummer: HY-170451
• Alternativnummer: MCE-HY-170451-5MG,MCE-HY-170451-50MG,MCE-HY-170451-100MG,MCE-HY-170451-10MG,MCE-HY-170451-25MG,MCE-HY-170451-1MG
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien
• Alternative Synonym: KT-253

Produktbeschreibung

Seldegamadlin (KT-253) is a selective p53 stabilizer and a MDM2 PROTAC degrader (DC50 = 0.4 nM). Seldegamadlin inhibits the proliferation of cancer cell RS4,11 with an IC50 of 0.3 nM, arrests the cell cycle at G2/M phase, and induces apoptosis. Seldegamadlin upregulates p53 activity and overcomes the p53-MDM2 feedback loop. Seldegamadlin can be used for the study of hematologic and solid tumors, such as acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). (Pink: ligand for target protein MDM2 ligand 4 (HY-170452), Black: linker (HY-W001478), Blue: ligand for E3 ligase cereblon (HY-163927))[1][2][3][4].

Produkteigenschaften

• Molekulargewicht: 912.87
• Reinheit: 98.53
• CAS Nummer: [2713618-08-5]
• Formel: C48H52Cl2FN7O6
• Target-Kategorie: Apoptosis,MDM-2/p53,PROTACs

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound