Seldegamadlin, CAS [[2713618-08-5]]

Product Overview

• Article Name: Seldegamadlin, CAS [[2713618-08-5]]
• Biozol Catalog Number: MCE-HY-170451
• Supplier Catalog Number: HY-170451
• Alternative Catalog Number: MCE-HY-170451-5MG,MCE-HY-170451-50MG,MCE-HY-170451-100MG,MCE-HY-170451-10MG,MCE-HY-170451-25MG,MCE-HY-170451-1MG
• Manufacturer: MedchemExpress
• Category: Biochemikalien
• Alternative Names: KT-253

Product Description

Seldegamadlin (KT-253) is a selective p53 stabilizer and a MDM2 PROTAC degrader (DC50 = 0.4 nM). Seldegamadlin inhibits the proliferation of cancer cell RS4,11 with an IC50 of 0.3 nM, arrests the cell cycle at G2/M phase, and induces apoptosis. Seldegamadlin upregulates p53 activity and overcomes the p53-MDM2 feedback loop. Seldegamadlin can be used for the study of hematologic and solid tumors, such as acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). (Pink: ligand for target protein MDM2 ligand 4 (HY-170452), Black: linker (HY-W001478), Blue: ligand for E3 ligase cereblon (HY-163927))[1][2][3][4].

Product Properties

• Molecular Weight: 912.87
• Purity: 98.53
• CAS Number: [2713618-08-5]
• Formula: C48H52Cl2FN7O6
• Target: Apoptosis,MDM-2/p53,PROTACs

Application Notes

• Application Notes: MCE Product type: Reference compound