TDI-015051, CAS [[3052313-73-9]] Preis auf Anfrage

Produktübersicht

• Artikelname: TDI-015051, CAS [[3052313-73-9]] Preis auf Anfrage
• Artikelnummer: MCE-HY-170524
• Hersteller Artikelnummer: HY-170524
• Alternativnummer: MCE-HY-170524-1UNIT
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

TDI-015051 is an orally active inhibitor for SARS-CoV-2 nonstructural protein 14 (NSP14) with an IC50 0.15 nM. TDI-015051 inhibits SARS-CoV-2 NSP14 in Huh-7.5 cell (EC50=11.4 nM) and in ACE2-TMPRSS2 expressing A549 cell (EC50=64.7 nM). TDI-015051 also inhibits other coronaviruses like alpha-hCoV-NL63, alpha-hCoV-229E and beta-hCoV-MERS with IC50s of 1.7, 2.6 and 3.6 nM, respectively. TDI-015051 binds to the SAH-stabilized cap binding pocket, inhibits viral RNA methylation and viral replication, and exhibits anti-infectious activity in mouse models[1].

Produkteigenschaften

• Molekulargewicht: 471.50
• CAS Nummer: [3052313-73-9]
• Formel: C22H22FN5O4S
• Target-Kategorie: DNA Methyltransferase,SARS-CoV

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound