TDI-015051, CAS [[3052313-73-9]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-170524
Supplier Catalog Number:
HY-170524
Alternative Catalog Number:
MCE-HY-170524-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
TDI-015051 is an orally active inhibitor for SARS-CoV-2 nonstructural protein 14 (NSP14) with an IC50 0.15 nM. TDI-015051 inhibits SARS-CoV-2 NSP14 in Huh-7.5 cell (EC50=11.4 nM) and in ACE2-TMPRSS2 expressing A549 cell (EC50=64.7 nM). TDI-015051 also inhibits other coronaviruses like alpha-hCoV-NL63, alpha-hCoV-229E and beta-hCoV-MERS with IC50s of 1.7, 2.6 and 3.6 nM, respectively. TDI-015051 binds to the SAH-stabilized cap binding pocket, inhibits viral RNA methylation and viral replication, and exhibits anti-infectious activity in mouse models[1].
Molecular Weight:
471.50
CAS Number:
[3052313-73-9]
Formula:
C22H22FN5O4S
Target:
DNA Methyltransferase,SARS-CoV
Application Notes:
MCE Product type: Reference compound
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