TRPV1-IN-3 (compound 14) is a TRPV1 inhibitor that can be used for the research of idiopathic pulmonary fibrosis. TRPV1-IN-3 affects the expression of fibrosis markers collagen I and alpha-SMA by inhibiting the TGF-beta/Smads and MAPK pathways, thereby exerting antifibrotic activity in vitro (IC50=0.51 µM). TRPV1-IN-3 significantly inhibits collagen deposition in lung tissue, improves the alveolar structure, and also increases the survival rate of mice with pulmonary fibrosis induced by Bleomycin (HY-108345)[1].
Molekulargewicht:
296.36
CAS Nummer:
[87657-67-8]
Formel:
C19H20O3
Target-Kategorie:
TRP Channel
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
