TRPV1-IN-3 (compound 14) is a TRPV1 inhibitor that can be used for the research of idiopathic pulmonary fibrosis. TRPV1-IN-3 affects the expression of fibrosis markers collagen I and alpha-SMA by inhibiting the TGF-beta/Smads and MAPK pathways, thereby exerting antifibrotic activity in vitro (IC50=0.51 µM). TRPV1-IN-3 significantly inhibits collagen deposition in lung tissue, improves the alveolar structure, and also increases the survival rate of mice with pulmonary fibrosis induced by Bleomycin (HY-108345)[1].
Molecular Weight:
296.36
CAS Number:
[87657-67-8]
Formula:
C19H20O3
Target:
TRP Channel
Application Notes:
MCE Product type: Reference compound1
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