YW-N-7 (TFA) is a PROTAC that targets both the inhibition and degradation of RET kinase, with a DC50 of 88 nM. YW-N-7 (TFA) exhibits antitumor activity in a KIF5B-RET-driven xenograft mouse tumor model and can be used in the area of cancer (Structure: red part represents the target protein ligand: HY-170856, blue part represents the E3 ligase ligand: HY-1708557, black part represents the linker, E3 ligase ligand + linker: HY-170858)[1].
Molekulargewicht:
1129.19
Formel:
C58H63F3N12O9
Target-Kategorie:
PROTACs,RET
Anwendungsbeschreibung:
MCE Product type: Reference compound1
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
