YW-N-7 (TFA) is a PROTAC that targets both the inhibition and degradation of RET kinase, with a DC50 of 88 nM. YW-N-7 (TFA) exhibits antitumor activity in a KIF5B-RET-driven xenograft mouse tumor model and can be used in the area of cancer (Structure: red part represents the target protein ligand: HY-170856, blue part represents the E3 ligase ligand: HY-1708557, black part represents the linker, E3 ligase ligand + linker: HY-170858)[1].
Molecular Weight:
1129.19
Formula:
C58H63F3N12O9
Target:
PROTACs,RET
Application Notes:
MCE Product type: Reference compound
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