P2Y14 antagonist 1 (compound 45) is a high selective and orally active P2Y14R antagonist with an IC50 of 0.70 nM. P2Y14R antagonist 1 demonstrates significant anti-inflammatory efficacy, effectively mitigating the pulmonary infiltration of immune cells and inflammatory response through suppressing the NLRP3 signaling pathway. P2Y14R antagonist 1 has the potential for the research of acute lung injury[1].
Molekulargewicht:
399.44
Formel:
C24H21N3O3
Target-Kategorie:
NOD-like Receptor (NLR),P2Y Receptor
Anwendungsbeschreibung:
MCE Product type: Reference compound1
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