P2Y14 antagonist 1 (compound 45) is a high selective and orally active P2Y14R antagonist with an IC50 of 0.70 nM. P2Y14R antagonist 1 demonstrates significant anti-inflammatory efficacy, effectively mitigating the pulmonary infiltration of immune cells and inflammatory response through suppressing the NLRP3 signaling pathway. P2Y14R antagonist 1 has the potential for the research of acute lung injury[1].
Molecular Weight:
399.44
Formula:
C24H21N3O3
Target:
NOD-like Receptor (NLR),P2Y Receptor
Application Notes:
MCE Product type: Reference compound
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