PROTAC CDK9 degrader-11, CAS [[3039540-19-4]] Preis auf Anfrage

Produktübersicht

• Artikelname: PROTAC CDK9 degrader-11, CAS [[3039540-19-4]] Preis auf Anfrage
• Artikelnummer: MCE-HY-170978
• Hersteller Artikelnummer: HY-170978
• Alternativnummer: MCE-HY-170978-1UNIT
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

PROTAC CDK9 degrader-11 (Compound C3) is an orally active PROTAC degrader for CDK9 with DC50 of 1.09 nM. PROTAC CDK9 degrader-11 exhibits cytotoxicity in multi small cell lung cancer cell with IC50 of nanomolar levels. PROTAC CDK9 degrader-11 arrests cell cycle at G0/G1 phase, inhibits the cell invasion in DMS114 and DMS53 cell. PROTAC CDK9 degrader-11 exhibits antitumor efficacy in NCI-H446 xenograft mouse models[1].(Pink: ligand for target protein CDK9 ligand 3 (HY-170979), Black: linker, Blue: ligand for E3 ligase Cereblon E3 ligase Ligand 56 (HY-W247437))

Produkteigenschaften

• Molekulargewicht: 807.77
• CAS Nummer: [3039540-19-4]
• Formel: C39H48Cl2N10O5
• Target-Kategorie: CDK,PROTACs

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound