PROTAC ROR1 degrader-1 (Compound 11d) is a PROTAC degrader for pseudokinase ROR1 that degrades ROR1 in NSCLC cells with a DC50s of 40-80 nM. PROTAC ROR1 degrader-1 causes the cleavage of PARP and induces apoptosis in NCI-H23[1]. (Pink: ligand for target protein ROR1 ligand-1 (HY-170996), Black: linker (HY-W014787), Blue: ligand for VHL E3 ligase (S,R,S)-AHPC (HY-125845))
Molekulargewicht:
1081.22
Formel:
C55H74BrN11O5S
Target-Kategorie:
Apoptosis,PROTACs,ROR
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
