PROTAC ROR1 degrader-1 (Compound 11d) is a PROTAC degrader for pseudokinase ROR1 that degrades ROR1 in NSCLC cells with a DC50s of 40-80 nM. PROTAC ROR1 degrader-1 causes the cleavage of PARP and induces apoptosis in NCI-H23[1]. (Pink: ligand for target protein ROR1 ligand-1 (HY-170996), Black: linker (HY-W014787), Blue: ligand for VHL E3 ligase (S,R,S)-AHPC (HY-125845))
Molecular Weight:
1081.22
Formula:
C55H74BrN11O5S
Target:
Apoptosis,PROTACs,ROR
Application Notes:
MCE Product type: Reference compound
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