RS47 (Compound 1a) is a selective inhibitor of the non-canonical NF-kappaB signaling pathway targeting RelB with a Kd of 1.1 µM. RS47 competitively blocks RelB binding to target DNA, inhibiting downstream gene (e.g., BCL3, PIM2) expression, thereby suppressing tumor cell proliferation. RS47 is promising for research of cancers with aberrant activation of the non-canonical NF-kappaB pathway, such as colorectal cancer and B lymphoma[1][2].
Molekulargewicht:
354.43
Reinheit:
98
CAS Nummer:
[301655-16-3]
Formel:
C18H18N4O2S
Target-Kategorie:
NF-kappaB
Anwendungsbeschreibung:
MCE Product type: Reference compound
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