RS47 is a selective RelB inhibitor with a Kd value of 1.1 µM. RS47 also acts as an inhibitor of HCV replication. RS47 can block the non-canonical NF-kappaB signaling pathway without affecting the canonical pathway. RS47 exerts anti-tumor effects of inhibiting proliferation and promoting apoptosis on colorectal cancer, B-cell lymphoma and other related tumors both in vitro and in vivo by disrupting the binding of RelB to target DNA. RS47 can be used for the research of tumors and infectious diseases[1][2].
Molecular Weight:
354.43
Purity:
98
CAS Number:
[301655-16-3]
Formula:
C18H18N4O2S
Target:
Apoptosis,c-Myc,HCV,NF-kappaB,Pim
Application Notes:
MCE Product type: Reference compound
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