H122 is a PROTAC degrader for TEAD that degrades TEAD1 with a DC50 of 3 nM, and exhibits good affinity to TEAD2, TEAD3, and TEAD4 with Ki of 2.0, 3.6 and 1.6 nM. H122 downregulates the expression of Myc. H122 inhibits the cell growth of MSTO-211H and NCI-H226 with IC50 of 21.3 nM and 0.6 nM, and exhibits antitumor efficacy in mouse models[1]. (Pink: ligand for target protein (HY-151525), Black: linker (HY-W573128), Blue: ligand for E3 ligase Cereblon (HY-W087383))
Molekulargewicht:
838.32
Reinheit:
98.33
Formel:
C45H45ClFN5O8
Target-Kategorie:
c-Myc,PROTACs,YAP
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
