H122 is a PROTAC degrader for TEAD that degrades TEAD1 with a DC50 of 3 nM, and exhibits good affinity to TEAD2, TEAD3, and TEAD4 with Ki of 2.0, 3.6 and 1.6 nM. H122 downregulates the expression of Myc. H122 inhibits the cell growth of MSTO-211H and NCI-H226 with IC50 of 21.3 nM and 0.6 nM, and exhibits antitumor efficacy in mouse models[1]. (Pink: ligand for target protein (HY-151525), Black: linker (HY-W573128), Blue: ligand for E3 ligase Cereblon (HY-W087383))
Molecular Weight:
838.32
Purity:
98.33
Formula:
C45H45ClFN5O8
Target:
c-Myc,PROTACs,YAP
Application Notes:
MCE Product type: Reference compound
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