LC-04-045 is a selective NIMA-related kinase 7 (NEK7) molecular glue degrader. LC-04-045 induces NEK7 degradation via the CRBN-based ubiquitin-proteasome system, dependent on the glycine 57-containing degron motif. LC-04-045 inhibits secretion of downstream cytokines IL-1beta and IL-18. LC-04-045 can be used for the research of lymphoblastic leukemia[1].
Molekulargewicht:
566.05
Reinheit:
99.56
Formel:
C32H28ClN5O3
Target-Kategorie:
Interleukin Related,Molecular Glues,NEKs
Anwendungsbeschreibung:
MCE Product type: Reference compound
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