PI3K-IN-59 (Compound 3d) is a PI3K inhibitor (IC50: 17.44 µM). PI3K-IN-59 has significant antiproliferative activity and exhibits potent inhibitory effects on breast cancer 4T1 cells (IC50: 3.70 µM) and colon cancer CT26 cells (IC50: 1.98 µM) as well as human breast cancer cells (IC50: 19.72 µM). PI3K-IN-59 exerts a dual anti-tumor mechanism by inhibiting PI3Kalpha enzymatic activity and triggering the Fenton reaction to generate hydroxyl radicals (OH). PI3K-IN-59 shows promising anti-4T1 tumor effects and is suitable for synergistic targeting studies in breast and colon cancers[1].
Molekulargewicht:
536.40
Formel:
C25H32FeN6O4
Target-Kategorie:
PI3K,Reactive Oxygen Species (ROS)
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
