PI3K-IN-59 (Compound 3d) is a PI3K inhibitor (IC50: 17.44 µM). PI3K-IN-59 has significant antiproliferative activity and exhibits potent inhibitory effects on breast cancer 4T1 cells (IC50: 3.70 µM) and colon cancer CT26 cells (IC50: 1.98 µM) as well as human breast cancer cells (IC50: 19.72 µM). PI3K-IN-59 exerts a dual anti-tumor mechanism by inhibiting PI3Kalpha enzymatic activity and triggering the Fenton reaction to generate hydroxyl radicals (OH). PI3K-IN-59 shows promising anti-4T1 tumor effects and is suitable for synergistic targeting studies in breast and colon cancers[1].
Molecular Weight:
536.40
Formula:
C25H32FeN6O4
Target:
PI3K,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
* VAT and and shipping costs not included. Errors and price changes excepted
