EGFR-IN-154 (compound 4c) is an EGFR inhibitor with EC50 values of 0.16 µM, 21.73 µM and 41.56 µM against EGFR Del19, EGFR WT and EGFR L858R, respectively. EGFR-IN-154 shows anticancer activity on various cance cell lines. EGFR-IN-154 induces mitochondrial apoptosis, and decreases pERK1/2 and pAkt levels, but increases pJNK and pp38 levels[1].
Molekulargewicht:
363.41
Formel:
C20H21N5O2
Target-Kategorie:
Akt,EGFR,JNK,p38 MAPK,PERK
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
