EGFR-IN-154 (compound 4c) is an EGFR inhibitor with EC50 values of 0.16 µM, 21.73 µM and 41.56 µM against EGFR Del19, EGFR WT and EGFR L858R, respectively. EGFR-IN-154 shows anticancer activity on various cance cell lines. EGFR-IN-154 induces mitochondrial apoptosis, and decreases pERK1/2 and pAkt levels, but increases pJNK and pp38 levels[1].
Molecular Weight:
363.41
Formula:
C20H21N5O2
Target:
Akt,EGFR,JNK,p38 MAPK,PERK
Application Notes:
MCE Product type: Reference compound
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