beta-Glu-PAB(CH2NH2)-Exatecan, CAS [[3025108-11-3]]

Produktübersicht

• Artikelname: beta-Glu-PAB(CH2NH2)-Exatecan, CAS [[3025108-11-3]]
• Artikelnummer: MCE-HY-173703
• Hersteller Artikelnummer: HY-173703
• Alternativnummer: MCE-HY-173703-5MG,MCE-HY-173703-1MG,MCE-HY-173703-10MG
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

beta-Glu-PAB(CH2NH2)-Exatecan (Compound 9a) is a topoisomerase I inhibitor. beta-Glu-PAB(CH2NH2)-Exatecan binds to the topoisomerase I-DNA complex to prevent DNA strand reconnection, thereby inducing DNA breakage and cell apoptosis. beta-Glu-PAB(CH2NH2)-Exatecan can be specifically cleaved by beta-glucuronidase highly expressed in the tumor microenvironment to release Exatecan for cytotoxic effect. beta-Glu-PAB(CH2NH2)-Exatecan is also an intermediate of Mal((3S,3aR,6S,6aR) -hexahydrofuro [3, 2-B]furan-3,6-diamine-PEG12)-beta -Glu-Pab-Exatecan. beta-Glu-PAB(CH2NH2)-Exatecan is promising for research of cancers[1].

Produkteigenschaften

• Molekulargewicht: 790.74
• Reinheit: 96.60
• CAS Nummer: [3025108-11-3]
• Formel: C39H39FN4O13
• Target-Kategorie: Topoisomerase

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: ADC Related