beta-Glu-PAB(CH2NH2)-Exatecan, CAS [[3025108-11-3]]

Product Overview

• Article Name: beta-Glu-PAB(CH2NH2)-Exatecan, CAS [[3025108-11-3]]
• Biozol Catalog Number: MCE-HY-173703
• Supplier Catalog Number: HY-173703
• Alternative Catalog Number: MCE-HY-173703-5MG,MCE-HY-173703-1MG,MCE-HY-173703-10MG
• Manufacturer: MedchemExpress
• Category: Biochemikalien

Product Description

beta-Glu-PAB(CH2NH2)-Exatecan (Compound 9a) is a topoisomerase I inhibitor. beta-Glu-PAB(CH2NH2)-Exatecan binds to the topoisomerase I-DNA complex to prevent DNA strand reconnection, thereby inducing DNA breakage and cell apoptosis. beta-Glu-PAB(CH2NH2)-Exatecan can be specifically cleaved by beta-glucuronidase highly expressed in the tumor microenvironment to release Exatecan for cytotoxic effect. beta-Glu-PAB(CH2NH2)-Exatecan is also an intermediate of Mal((3S,3aR,6S,6aR) -hexahydrofuro [3, 2-B]furan-3,6-diamine-PEG12)-beta -Glu-Pab-Exatecan. beta-Glu-PAB(CH2NH2)-Exatecan is promising for research of cancers[1].

Product Properties

• Molecular Weight: 790.74
• Purity: 96.60
• CAS Number: [3025108-11-3]
• Formula: C39H39FN4O13
• Target: Topoisomerase

Application Notes

• Application Notes: MCE Product type: ADC Related