PROTAC HPK1 Degrader-4 (compound E3) is a selective and orally active PROTAC HPK1 degrader with a DC50 of 3.16 nM. PROTAC HPK1 Degrader-4 demonstrates >1000-fold selectivity over GLK. PROTAC HPK1 Degrader-4 promotes immune activation. PROTAC HPK1 Degrader-4 can be used for the study of colon cancer and lymphoma (Pink: ligand for target protein (HY-174355), Blue: ligand for E3 ligase CRBN (HY-45808), Black: Linker (HY-174356), Target protein ligand-linker Conjugate (HY-174357))[1].
Molekulargewicht:
790.91
Formel:
C46H46N8O5
Target-Kategorie:
MAP4K,PROTACs
Anwendungsbeschreibung:
MCE Product type: Reference compound1
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
