PROTAC HPK1 Degrader-4 (compound E3) is a selective and orally active PROTAC HPK1 degrader with a DC50 of 3.16 nM. PROTAC HPK1 Degrader-4 demonstrates >1000-fold selectivity over GLK. PROTAC HPK1 Degrader-4 promotes immune activation. PROTAC HPK1 Degrader-4 can be used for the study of colon cancer and lymphoma (Pink: ligand for target protein (HY-174355), Blue: ligand for E3 ligase CRBN (HY-45808), Black: Linker (HY-174356), Target protein ligand-linker Conjugate (HY-174357))[1].
Molecular Weight:
790.91
Formula:
C46H46N8O5
Target:
MAP4K,PROTACs
Application Notes:
MCE Product type: Reference compound1
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