USP7-IN-18, CAS [[3052223-40-9]] Preis auf Anfrage

Produktübersicht

• Artikelname: USP7-IN-18, CAS [[3052223-40-9]] Preis auf Anfrage
• Artikelnummer: MCE-HY-174301
• Hersteller Artikelnummer: HY-174301
• Alternativnummer: MCE-HY-174301-1UNIT
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

USP7-IN-18 is a naphthalene derivative. USP7-IN-18 is a selective USP7 inhibitor (IC50 : 130.9 nM), with no or very weak inhibition of the other 8 DUBs including USP47. USP7-IN-18 specifically binds to the catalytic domain of USP7, blocking its deubiquitinase activity. USP7-IN-18 causes degradation of the oncogenic proteins MDM2 and DNMT1, and also degrades the novel target PCLAF. USP7-IN-18 activates the p53-p21 pathway. USP7-IN-18 exerts anti-tumor effects in colon cancer animal models and reshapes the tumor immune microenvironment. USP7-IN-18 achieves both direct cytotoxic and immune-synergistic anti-tumor actions[1].

Produkteigenschaften

• Molekulargewicht: 546.08
• CAS Nummer: [3052223-40-9]
• Formel: C30H28ClN3O3S
• Target-Kategorie: Deubiquitinase,DNA Methyltransferase,MDM-2/p53

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound1