USP7-IN-18, CAS [[3052223-40-9]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-174301
Supplier Catalog Number:
HY-174301
Alternative Catalog Number:
MCE-HY-174301-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
USP7-IN-18 is a naphthalene derivative. USP7-IN-18 is a selective USP7 inhibitor (IC50 : 130.9 nM), with no or very weak inhibition of the other 8 DUBs including USP47. USP7-IN-18 specifically binds to the catalytic domain of USP7, blocking its deubiquitinase activity. USP7-IN-18 causes degradation of the oncogenic proteins MDM2 and DNMT1, and also degrades the novel target PCLAF. USP7-IN-18 activates the p53-p21 pathway. USP7-IN-18 exerts anti-tumor effects in colon cancer animal models and reshapes the tumor immune microenvironment. USP7-IN-18 achieves both direct cytotoxic and immune-synergistic anti-tumor actions[1].
Molecular Weight:
546.08
CAS Number:
[3052223-40-9]
Formula:
C30H28ClN3O3S
Target:
Deubiquitinase,DNA Methyltransferase,MDM-2/p53
Application Notes:
MCE Product type: Reference compound1
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