PI3Kdelta/HDAC6-IN-1, CAS [[3075011-99-0]] Preis auf Anfrage

Produktübersicht

• Artikelname: PI3Kdelta/HDAC6-IN-1, CAS [[3075011-99-0]] Preis auf Anfrage
• Artikelnummer: MCE-HY-174396
• Hersteller Artikelnummer: HY-174396
• Alternativnummer: MCE-HY-174396-1UNIT
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

PI3Kdelta/HDAC6-IN-1 (Compound 22E) is an orally active and dual inhibitor of PI3Kdelta and HDAC6 with IC50 values of 2.4 nM and 6.2 nM, respectively. PI3Kdelta/HDAC6-IN-1 exhibits potent antiproliferative effects on non-Hodgkin lymphoma (NHL) cells and possesses in vivo antitumor activity without significant toxicity. PI3Kdelta/HDAC6-IN-1 arrests the cell cycle at the G0/G1 phase and induces apoptosis. PI3Kdelta/HDAC6-IN-1 blocks the PI3K/AKT/mTOR signaling pathway and increases the acetylation levels of alpha-tubulin and histone H3[1].

Produkteigenschaften

• Molekulargewicht: 650.73
• CAS Nummer: [3075011-99-0]
• Formel: C34H38N10O4
• Target-Kategorie: Apoptosis,Bcl-2 Family,Caspase,HDAC,Histone Methyltransferase,Microtubule/Tubulin,PI3K,Reactive Oxygen Species (ROS)

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound