PI3Kdelta/HDAC6-IN-1, CAS [[3075011-99-0]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-174396
Supplier Catalog Number:
HY-174396
Alternative Catalog Number:
MCE-HY-174396-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
PI3Kdelta/HDAC6-IN-1 (Compound 22E) is an orally active and dual inhibitor of PI3Kdelta and HDAC6 with IC50 values of 2.4 nM and 6.2 nM, respectively. PI3Kdelta/HDAC6-IN-1 exhibits potent antiproliferative effects on non-Hodgkin lymphoma (NHL) cells and possesses in vivo antitumor activity without significant toxicity. PI3Kdelta/HDAC6-IN-1 arrests the cell cycle at the G0/G1 phase and induces apoptosis. PI3Kdelta/HDAC6-IN-1 blocks the PI3K/AKT/mTOR signaling pathway and increases the acetylation levels of alpha-tubulin and histone H3[1].
Molecular Weight:
650.73
CAS Number:
[3075011-99-0]
Formula:
C34H38N10O4
Target:
Apoptosis,Bcl-2 Family,Caspase,HDAC,Histone Methyltransferase,Microtubule/Tubulin,PI3K,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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