FLT3-IN-32 (hydrochloride), CAS [[3047195-66-1]] Preis auf Anfrage

Produktübersicht

• Artikelname: FLT3-IN-32 (hydrochloride), CAS [[3047195-66-1]] Preis auf Anfrage
• Artikelnummer: MCE-HY-174437B
• Hersteller Artikelnummer: HY-174437B
• Alternativnummer: MCE-HY-174437B-1UNIT
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

FLT3-IN-32 hydrochloride is a potent and orally active FLT3 inhibitor with an IC50s of 0.29 nM, 0.77 nM and 2.07 nM against FLT3-ITD, FLT3-D835Y and FLT-N676K. FLT3-IN-32 hydrochloride reduces the phosphorylation of FLT3 and its downstream signaling molecules (STAT5, MAPK, AKT) to induce FLT3-mutated Ba/F3 cells apoptosis. FLT3-IN-32 hydrochloride shows significant anti-tumor efficacy in n the MV4-11 xenograft model. FLT3-IN-32 hydrochloride can be used for the study of acute myeloid leukemia (AML)[1].

Produkteigenschaften

• Molekulargewicht: 552.02
• CAS Nummer: [3047195-66-1]
• Formel: C28H30ClN5O5
• Target-Kategorie: Akt,Apoptosis,FLT3,p38 MAPK,STAT

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound1