FLT3-IN-32 (hydrochloride), CAS [[3047195-66-1]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-174437B
Supplier Catalog Number:
HY-174437B
Alternative Catalog Number:
MCE-HY-174437B-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
FLT3-IN-32 hydrochloride is a potent and orally active FLT3 inhibitor with an IC50s of 0.29 nM, 0.77 nM and 2.07 nM against FLT3-ITD, FLT3-D835Y and FLT-N676K. FLT3-IN-32 hydrochloride reduces the phosphorylation of FLT3 and its downstream signaling molecules (STAT5, MAPK, AKT) to induce FLT3-mutated Ba/F3 cells apoptosis. FLT3-IN-32 hydrochloride shows significant anti-tumor efficacy in n the MV4-11 xenograft model. FLT3-IN-32 hydrochloride can be used for the study of acute myeloid leukemia (AML)[1].
Molecular Weight:
552.02
CAS Number:
[3047195-66-1]
Formula:
C28H30ClN5O5
Target:
Akt,Apoptosis,FLT3,p38 MAPK,STAT
Application Notes:
MCE Product type: Reference compound1
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