JP-163-16 is a RelA/p65 PROTAC degrader. JP-163-16 selectively reduces the expression of RelA/p65 in a proteasome-dependent manner in cells. JP-163-16 can induce cell apoptosis by inhibiting the NF-kappaB signaling pathway. JP-163-16 can be used for research on RelA/p65-dependent tumours, such as chronic lymphocytic leukaemia (CLL). (Pink: RelA/p65 Ligand (HY-174865), Blue: CRBN Ligand (HY-A0003), Black: Linker, CRBN Ligand+Linker (HY-160241))[1].
Molekulargewicht:
777.86
Reinheit:
96.61
Formel:
C42H47N7O8
Target-Kategorie:
Apoptosis,NF-kappaB,PROTACs
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
