JP-163-16 is a RelA/p65 PROTAC degrader. JP-163-16 selectively reduces the expression of RelA/p65 in a proteasome-dependent manner in cells. JP-163-16 can induce cell apoptosis by inhibiting the NF-kappaB signaling pathway. JP-163-16 can be used for research on RelA/p65-dependent tumours, such as chronic lymphocytic leukaemia (CLL). (Pink: RelA/p65 Ligand (HY-174865), Blue: CRBN Ligand (HY-A0003), Black: Linker, CRBN Ligand+Linker (HY-160241))[1].
Molecular Weight:
777.86
Purity:
96.61
Formula:
C42H47N7O8
Target:
Apoptosis,NF-kappaB,PROTACs
Application Notes:
MCE Product type: Reference compound
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