diABZI-i is a orthosteric STING inhibitor. diABZI-i significantly inhibits cGAMP-induced IFNbeta in PBMCs with an IC50 of 49 nM. diABZI-i also activates V155M SAVI constitutive signaling in STING V155M THP-1 cells model with potent agonism (EC50: 17 nM). diABZI-i can be used for monogenic autoinflammatory disease like SAVI disease research[1].
Molekulargewicht:
854.96
Formel:
C45H50N12O6
Target-Kategorie:
STING
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
