diABZI-i is a orthosteric STING inhibitor. diABZI-i significantly inhibits cGAMP-induced IFNbeta in PBMCs with an IC50 of 49 nM. diABZI-i also activates V155M SAVI constitutive signaling in STING V155M THP-1 cells model with potent agonism (EC50: 17 nM). diABZI-i can be used for monogenic autoinflammatory disease like SAVI disease research[1].
Molecular Weight:
854.96
Formula:
C45H50N12O6
Target:
STING
Application Notes:
MCE Product type: Reference compound
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