Mutant IDH1-IN-7 Preis auf Anfrage
Artikelnummer:
MCE-HY-175213
| Artikelname: |
Mutant IDH1-IN-7 Preis auf Anfrage |
| Artikelnummer: |
MCE-HY-175213 |
| Hersteller Artikelnummer: |
HY-175213 |
| Alternativnummer: |
MCE-HY-175213-1UNIT |
| Hersteller: |
MedchemExpress |
| Kategorie: |
Biochemikalien |
| Mutant IDH1-IN-7 is a highly selective Isocitrate Dehydrogenase 1 (IDH1) R132H (IC50 = 0.26 µM, Kd = 2.1 µM)/R132C (IC50 = 1.1 µM) inhibitor. Mutant IDH1-IN-7 has no inhibitory effect on wild-type IDH1, IDH2-wt, and IDH2 R140Q. Mutant IDH1-IN-7 inhibits 2-Hydroxyglutarate (2-HG) production in U87-MG R132H cells (EC50 = 0.55 µM). Mutant IDH1-IN-7 exhibits moderate antiproliferative effects on U87-MG R132H and HT-1080 cells[1]. |
| Molekulargewicht: |
456.54 |
| Formel: |
C27H28N4O3 |
| Target-Kategorie: |
Isocitrate Dehydrogenase (IDH) |
| Anwendungsbeschreibung: |
MCE Product type: Reference compound |
