STAT3/NF-kappaB-IN-1 is a potentSTAT3 and NF-kappaB inhibitor with IC50s of 5.86 (STAT3) and 4.22 µM (NF-kappaB) in 4T1 cells. STAT3/NF-kappaB-IN-1 is able to induce apoptosis via its upregulation on key apoptotic regulators, caspases-3/9, Bax and downregulation of Bcl-2. STAT3/NF-kappaB-IN-1 exerts considerable anticancer activity against breast cancer cell lines and reduces tumor volume in vivo. STAT3/NF-kappaB-IN-1 can be used for the study of breast cancer[1].
Molekulargewicht:
542.61
Formel:
C27H26N8O3S
Target-Kategorie:
Apoptosis,Bcl-2 Family,Caspase,NF-kappaB,STAT
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
