STAT3/NF-kappaB-IN-1 is a potentSTAT3 and NF-kappaB inhibitor with IC50s of 5.86 (STAT3) and 4.22 µM (NF-kappaB) in 4T1 cells. STAT3/NF-kappaB-IN-1 is able to induce apoptosis via its upregulation on key apoptotic regulators, caspases-3/9, Bax and downregulation of Bcl-2. STAT3/NF-kappaB-IN-1 exerts considerable anticancer activity against breast cancer cell lines and reduces tumor volume in vivo. STAT3/NF-kappaB-IN-1 can be used for the study of breast cancer[1].
Molecular Weight:
542.61
Formula:
C27H26N8O3S
Target:
Apoptosis,Bcl-2 Family,Caspase,NF-kappaB,STAT
Application Notes:
MCE Product type: Reference compound1
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