DDO-4033 is a SPOP inhibitor (IC50 = 16.9 µM, Kd = 15.1 µM). DDO-4033 impairs the malignant migration, invasion, and proliferation of clear cell renal cell carcinoma (ccRCC) cell lines. DDO-4033 disrupts SPOP recruitment to its substrate LATS1, inhibits its polyubiquitination and subsequent degradation, and upregulates LATS1 expression. DDO-4033 has promising antitumor activity and is promising for renal cell carcinoma research[1].
Molekulargewicht:
406.39
Formel:
C20H18N6O4
Target-Kategorie:
E1/E2/E3 Enzyme,YAP
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
