DDO-4033 is a SPOP inhibitor (IC50 = 16.9 µM, Kd = 15.1 µM). DDO-4033 impairs the malignant migration, invasion, and proliferation of clear cell renal cell carcinoma (ccRCC) cell lines. DDO-4033 disrupts SPOP recruitment to its substrate LATS1, inhibits its polyubiquitination and subsequent degradation, and upregulates LATS1 expression. DDO-4033 has promising antitumor activity and is promising for renal cell carcinoma research[1].
Molecular Weight:
406.39
Formula:
C20H18N6O4
Target:
E1/E2/E3 Enzyme,YAP
Application Notes:
MCE Product type: Reference compound
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