SOS1-IN-21, CAS [[2767633-04-3]] Preis auf Anfrage

Produktübersicht

• Artikelname: SOS1-IN-21, CAS [[2767633-04-3]] Preis auf Anfrage
• Artikelnummer: MCE-HY-175326
• Hersteller Artikelnummer: HY-175326
• Alternativnummer: MCE-HY-175326-1UNIT
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

SOS1-IN-21 is an orally active inhibitor of son of Sevenless 1 (SOS1) with an IC50 of 15 nM. SOS1 is a guanine nucleotide exchange factor (GEF) that activates KRAS by facilitating the exchange of GDP for GTP. SOS1-IN-21 exhibits potent antiproliferative activity, with IC50 values of 16 nM in NCI-H358 and 17 nM in Mia Paca-2 cell proliferation assays. SOS1-IN-21 exhibits significant antitumor activity in the Mia Paca-2 xenograft model. SOS1-IN-21 can be used for the study of KRAS mutant tumors, such as pancreatic cancer[1].

Produkteigenschaften

• Molekulargewicht: 493.52
• CAS Nummer: [2767633-04-3]
• Formel: C25H30F3N3O4
• Target-Kategorie: SOS1

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound