SOS1-IN-21, CAS [[2767633-04-3]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-175326
Supplier Catalog Number:
HY-175326
Alternative Catalog Number:
MCE-HY-175326-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
SOS1-IN-21 is an orally active inhibitor of son of Sevenless 1 (SOS1) with an IC50 of 15 nM. SOS1 is a guanine nucleotide exchange factor (GEF) that activates KRAS by facilitating the exchange of GDP for GTP. SOS1-IN-21 exhibits potent antiproliferative activity, with IC50 values of 16 nM in NCI-H358 and 17 nM in Mia Paca-2 cell proliferation assays. SOS1-IN-21 exhibits significant antitumor activity in the Mia Paca-2 xenograft model. SOS1-IN-21 can be used for the study of KRAS mutant tumors, such as pancreatic cancer[1].
Molecular Weight:
493.52
CAS Number:
[2767633-04-3]
Formula:
C25H30F3N3O4
Target:
SOS1
Application Notes:
MCE Product type: Reference compound
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