Kv7.2/Kv7.3 activator-3, CAS [[1361107-81-4]] Preis auf Anfrage

Produktübersicht

• Artikelname: Kv7.2/Kv7.3 activator-3, CAS [[1361107-81-4]] Preis auf Anfrage
• Artikelnummer: MCE-HY-175340
• Hersteller Artikelnummer: HY-175340
• Alternativnummer: MCE-HY-175340-1UNIT
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

Kv7.2/Kv7.3 activator-3 (GRT-X) is an orally active Kv7.2/Kv7.3 and TSPO activator. Kv7.2/Kv7.3 activator-3 activates Kv7.2/Kv7.3, Kv7.4, and Kv7.5 with EC50 values of 0.37, 2.06, and 0.75 µM, respectively, and binds to TSPO with Ki values of 0.07 µM (rat membrane) and 4.60 µM (human U-118 MG cells). Kv7.2/Kv7.3 activator-3 prevents motor neuron degeneration in mice and humans conditioned by ALS/FTD astrocytes. Kv7.2/Kv7.3 activator-3 stimulates dorsal root ganglion axonal growth through TSPO and Kv7.2/3 activation. Kv7.2/Kv7.3 activator-3 has anti-epileptic effects in epileptic seizure models. Kv7.2/Kv7.3 activator-3 reduces pain hypersensitivity in patients with diabetic neuropathy, promotes neuronal survival and regeneration after cervical neuropathy in rats, and accelerates the recovery of normal function of sensory and motor neurons[1][2][3][4].

Produkteigenschaften

• Molekulargewicht: 436.40
• CAS Nummer: [1361107-81-4]
• Formel: C22H20F4N2O3
• Target-Kategorie: Potassium Channel,TSPO

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound